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Anti-CASP3 Rabbit Polyclonal Antibody

Supplier: GeneTex

GTX24051

89352-082EA 632.43 USD

89352-082

Anti-CASP3 Rabbit Polyclonal Antibody

Antibodies

The caspase family of cysteine proteases play a key role in apoptosis. Caspase 3 (also known as CPP32, YAMA and apopain) is the most extensively studied apoptotic protein among caspase family members. Caspase 3 is synthesized as inactive pro-enzyme that is processed in cells undergoing apoptosis by self-proteolysis and/or cleavage by other upstream proteases (e.g. caspases 8, 9 and 10). The processed form of caspase 3 consists of large (17kD) and small (12kD) subunits which associate to form an active enzyme. Caspase 3 is cleaved at Asp28 - Ser29 and Asp175 - Ser176. The active caspase 3 proteolytically cleaves and activates other caspases (e.g. caspases 6, 7 and 9), as well as relevant targets in the cells (e.g. PARP and DFF).

Type: Primary
Antigen: CASP3
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype:
Reactivity: Bovine

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