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Anti-CASP3 Rabbit Polyclonal Antibody

Supplier: Genetex
GTX24051
The caspase family of cysteine proteases play a key role in apoptosis. Caspase 3 (also known as CPP32, YAMA and apopain) is the most extensively studied apoptotic protein among caspase family members. Caspase 3 is synthesized as inactive pro-enzyme that is processed in cells undergoing apoptosis by self-proteolysis and/or cleavage by other upstream proteases (e.g. caspases 8, 9 and 10). The processed form of caspase 3 consists of large (17kD) and small (12kD) subunits which associate to form an active enzyme. Caspase 3 is cleaved at Asp28 - Ser29 and Asp175 - Ser176. The active caspase 3 proteolytically cleaves and activates other caspases (e.g. caspases 6, 7 and 9), as well as relevant targets in the cells (e.g. PARP and DFF).

Type: Primary
Antigen: CASP3
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype:
Reactivity: Bovine




 

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Supplier No. VWR Catalog Number Unit Price Quantity
GTX24051 89352-082 Each (500µl) Retrieving Restricted

Temperature sensitive This Item is temperature-controlled and may have specific temperature and storage requirements for shipping/delivery.

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SPECIFICATIONS

Antigen Symbol CASP3
Antigen Name Caspase 3
Reactivity Bovine
Conjugation Unconjugated
Clonality Polyclonal
Antibody Type Primary
Host Rabbit
Isotype IgG
ImmunoChemistry Yes
Antigen Synonyms protein Yama, procaspase3, caspase-3, cysteine protease CPP32, SCA-1, Yama, apopain, SREBP cleavage activity 1, apoptosis-related cysteine protease, caspase 3, CPP32B, PARP cleavage protease, CPP32
Immunogen Recombinant full length protein (Human).
Purification IgG fraction
Storage Buffer 10mM PBS, pH 7.4 containing 0.2% BSA and 0.09% sodium azide
Storage Temperature Keep as concentrated solution, aliquot and store at 4°C. Do not freeze.
Tested Applications IHC-P, IHC-Fr
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