Cdk1 Inhibitor, Calbiochem®
Supplier: MilliporeSigma
N-(cis-2-Aminocyclohexyl)-N-(3-chlorophenyl)-9-ethyl-9H-purine-2,6-diamine
- Solubility: 10 mg/mL in DMSO
Off-white solid. A cell-permeable, potent, and selective inhibitor of Cdk1/cyclin B. It affects the activities of other kinases only at higher concentrations. It is also reported to induce mitochondrial damage and apoptosis in several human leukemia cell lines. At lower concentrations, an initial G2M cell cyle arrest and eventual apoptosis has been reported to occur in U937 cells.
Packed under an inert gas. Store frozen at –20°C (–4°F) and protect from light. Stable for 2 years. Following reconstitution, aliquot and freeze. Solution is stable for 3 months when frozen.
Formula:
C₁₉H₂₄ClN₇ MW: 385.9 g/mol |
CAS Number:
190654-01-4 |
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