Puromycin dihydrochloride ≥98% (by TLC), Calbiochem®
Puromycin is a protein synthesis inhibitor.
- Induces DNA fragmentation
- Premature release of nascent polypeptide chains
An aminonucleoside antibiotic that acts as a prokaryotic and eukaryotic protein synthesis inhibitor. Resembles the aminoacyl-adenylyl terminus of aminoacyl-tRNA and competes for binding to the A-site of the large ribosomal subunit.
Inhibits translation by causing premature release of nascent polypeptide chains. Induces DNA fragmentation in thymocytes and in human HL-60 leukemia cells.
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