Dextran sulfate sodium salt, M.W. ∼36000 - 50000, white powder, Colitis Grade


Synonyms: Dextran sulfate sodium from DextranDextran sulphate sodium from Dextran

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IC16011090EA 10750.53 USD
IC16011090 IC16011080 CA10015-620 CA10015-610 IC16011010 IC16011050 76203-054 76202-276 CA10015-608 IC16011001 CA10015-612 CA10015-618 CA10015-616
Dextran sulfate sodium salt, M.W. ∼36000 - 50000, white powder, Colitis Grade
Dextran sulphate sodium salt

Dextran sulfate is a polyanionic derivative of dextran produced by esterification of Dextran with chlorosulphonic acid. Dextran sulfate sodium (DSS) is the sodium salt which is a white to off-white powder freely soluble in water and salt solutions to form a stable, clear solution. The sulfur content is approximately 17% which corresponds to an average of 1.9 sulfate groups per glucosyl residue of the dextran molecule.

Dextran Sulfate Sodium (DSS) which has proven to have versatile value in Biomedical/clinical research. DSS can be used to study Colitis (Inflammatory Bowel disease) as well as an antiviral as agent.

Inflammatory Bowel Disease (IBD) is characterized by chronic and relapsing inflammation of the gastrointestinal tract which is associated with increased risk of developing colitis-associated cancer. Several animal models have been used to study colitis and one such model involves the oral administration of dextran sodium sulfate (DSS) in the drinking water of mice leading to chronic colitis. This DSS induced colitis model is spontaneous and is used to assess the therapeutic potential of treatments for IBD.

Formula: (C₆H₇Na₃O₁₄S₃)n
Storage Temperature: Ambient
MDL Number: MFCD00081551
CAS Number: 9011-18-1

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Specification Test Results

Identity Test Passes
Moisture 10%
Residue on Ignition 50%
Sulfur ~18 - 20%
Glucose 35 - 50%
pH (1% aq soln) 5 - 7.5
Specific Rotation +75° to +105°
Free Sulfate ≤0.2%

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