FK506 Binding Proteins (FKBPs) are intracellular receptors for the immuno-suppressive drug FK506. The FKBP/FK506 complex exerts its immunosuppressive effects by inhibiting calcineurin, a calcium- and calmodulin-dependent serine/threonine phosphatase that functions as a critical signaling molecule during T-cell activation.
- Reconstitute at 0.5 mg/ml in sterile PBS
- Dilute 0.5 μg/ml for Western blot
It binds to and inhibits calcineurin even in the absence of FK506, indicating that FKBP38 is a constitutively active inhibitor of calcineurin. Additionally, FKBP38 co‑immunoprecipitates with Bcl-2 and Bcl-xL, suggesting that FKBP38 may regulate apoptosis by anchoring Bcl‑2 and Bcl‑xL to mitochondrial membranes.
Caution: This product is for research use only and is not approved for use in humans or in clinical diagnosis.
Type: Primary
Antigen: FKBP38
Clonality: monoclonal
Clone: 391505
Conjugation: unconjugated
Epitope:
Host: Mouse
Isotype: IgG2b
Reactivity: Human, Mouse, Rabbit