Anti-SHANK3 Mouse Monoclonal Antibody (AT390) [Clone: S367-51]

Supplier: Rockland Immunochemicals
200-367-W72
75934-146EA 433.54 USD
75934-146
Anti-SHANK3 Mouse Monoclonal Antibody (AT390) [Clone: S367-51]
Antibodies
SHANK proteins are scaffolding adaptors that have been shown to integrate neurotransmitter receptors into the cortical cytoskeleton at postsynaptic densities. SHANK1-3 of the SHANK/ProSAP family are molecular scaffolds in the postsynaptic density (PSD). SHANK recruits betaPIX and PAK to dendritic spines to regulate postsynaptic structure and interacts with ionotropic receptor and metabotropic glutamate receptor complexes. Transcript splice variation in the Shank family influences the spectrum of Shank-interacting proteins in the PSDs of adult and developing brain to ensure normal development. Anti-SHANK1/SHANK3 is ideal for research in Neuroscience, including autism spectrum disorder, and Cell Adhesion.

Anti-SHANK1/SHANK3 ATTO 390 Conjugated Antibody is suitable for Western Blots, Immunohistochemistry and Immunocytochemistry. Expect a band approximately ~190kDa on specific lysates or tissues. It will cross react with SHANK1, but it will not cross react with SHANK2. Specific conditions for reactivity should be optimized by the end user.

Type: Primary
Antigen: SHANK3
Clonality: Monoclonal
Clone: S367-51
Conjugation: AT390
Epitope:
Host: Mouse
Isotype: IgG2a
Reactivity:
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