UBE2I

Supplier: Rockland Immunochemicals

009-001-U37 009-001-U37S
75933-346EA 318.75 USD
75933-346 75933-344
UBE2I
Proteins and Peptides
UBE2I control protein-HIS Epitope

  • Control Protein
  • PCA Assays
  • ImmunoBlot

UBE2I or ubiquitin-conjugating enzyme E2I is a member of the E2 ubiquitin-conjugating enzyme family which is required for post-replicative DNA damage repair. UBE21 also known as UBC9, plays a role DNA damage repair via interaction with WT1, which is able to impose a block in cell cycle progression in eukaryotic cells (1). Listeria and probably other pathogens, dampens the host response by decreasing the sumoylation level of proteins critical for infection by targeting UBC21, an essential enzyme of the SUMO pathway. UBC21 and the SUMO pathway are crucial for proper nuclear architecture, accurate chromosome segregation, and embryonic viability (2). UBE2I Protein is ideal for investigators involved in Signaling Proteins, Ubiquitin Proteins, Cancer, Cell Cycle, and Neurobiology research.

UBE2I Protein is stored in 50mM sodium phosphate, pH 7.0, 300mM NaCl, 150mM imidazole, 0.1mM PMSF, 0.25mM DTT, 25% glycerol. UBE2I Protein is suitable for use in Western Blot. Expect a band approximately ~19kDa on specific lysates or tissues. Specific conditions for reactivity should be optimized by the end user.
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