STAT5

Supplier: Rockland Immunochemicals

009-001-T56S 009-001-T56
75932-210EA 366.63 USD
75932-210 75932-212
STAT5
Proteins and Peptides
STAT5 control protein-HIS Epitope

  • Control Protein
  • PCA Assays
  • ImmunoBlot

STAT5 (signal transducers and activators of transcription 5) is a member of the STAT family and this protein is phosphorylated by receptor associated protein kinases in response to cytokines and growth factors (1). The differentiation of T helper (Th) cells is regulated by members of the STAT family of signaling molecules. In BCR-ABL-positive cells, STAT5 is constitutively activated by tyrosine phosphorylation. STAT5 activation results in upregulation of Bcl-XL and increased resistance to induction of apoptosis. STAT5 is involved in expression and growth hormone-mediated sexually dimorphic regulation of cytochrome P450 3A10/lithocholic acid 6 beta-hydroxylase (2). STAT5 Protein is ideal for investigators involved in Signaling Proteins, Transcription Proteins, Apoptosis/Autophagy, Cancer, ERK/MAPK Pathway, Inflammation, and JAK/STAT Pathway research.

STAT5 Protein is stored in 50mM sodium phosphate, pH 7.0, 300mM NaCl, 150mM imidazole, 0.1mM PMSF, 0.25mM DTT, 25% glycerol. STAT5 Protein is suitable for use in Western Blot and Kinase Assay. Expect a band approximately ~92kDa on specific lysates or tissues. Specific conditions for reactivity should be optimized by the end user.
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