SMAD3

Supplier: Rockland Immunochemicals

009-001-T39 009-001-T39S
75932-038EA 690.06 USD
75932-038 75932-036
SMAD3
Proteins and Peptides
SMAD3 control protein-GST fusion

  • Control Protein
  • PCA Assays
  • ImmunoBlot

SMAD3 is a direct mediator of transcriptional activation by the TGFβ receptor. The activity of SMAD3 is regulated by the TGFβ receptors, and SMAD3 is phosphorylated and associated with the ligand-bound receptor complex. TGFβ stimulation leads to phosphorylation and activation of SMAD3, which form a complex with SMAD4 that accumulate in the nucleus and regulate transcription of target genes such as CDK inhibitor (1). SMAD3 containing a C-terminal truncation acts as a dominant-negative inhibitor of the normal TGFβ response. SMAD3 is a major physiologic substrate of the G1 cyclin-dependent kinases CDK4 and CDK2 (2). SMAD3 Protein is ideal for investigators involved in Signaling Proteins, Transcription Proteins, AKT/PKB Pathway, Angiogenesis, Cancer, Cell Cycle, Cellular Stress, ERK/MAPK Pathway, Inflammation, JAK/STAT Pathway, JNK/SAPK Pathway, NfkB Pathway, and WNT Signaling research.

SMAD3 Protein is stored in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol. SMAD3 Protein is suitable for use in Western Blot and Kinase Assay. Expect a band approximately ~77kDa on specific lysates or tissues. Specific conditions for reactivity should be optimized by the end user.
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