SIRT6

Supplier: Rockland Immunochemicals
009-001-T36S 009-001-T36
75931-940EA 713.69 USD
75931-940 75931-938
SIRT6
Proteins and Peptides
SIRT6 control protein-GST fusion

  • Control Protein
  • PCA Assays
  • ImmunoBlot

SIRT6 is a member of the sirtuin family of proteins which are homologs to the yeast Sir2 protein. Sirtuin family contain a sirtuin core domain and are grouped into four classes with SIRT6 being a member of class IV. Human SIRT6 protein is a NAD(+)-dependent histone H3 lysine-9 deacetylase that modulates telomeric chromatin (1). SIRT6 associates specifically with telomeres and SIRT6 depletion leads to telomere dysfunction with end-to-end chromosomal fusions and premature cellular senescence. SIRT6 -/- mouse cells show that SIRT6 promotes resistance to DNA damage and suppresses genomic instability in association with a role in base excision repair (2). SIRT6 Protein is ideal for investigators involved in Signaling Proteins, Cancer, Cell Cycle, and Inflammation research.

SIRT6 Protein is stored in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol. SIRT6 Protein is suitable for use in Western Blot. Expect a band approximately ~66kDa on specific lysates or tissues. Specific conditions for reactivity should be optimized by the end user.
Order Now

Learn more

About VWR

Avantor is a vertically integrated, global supplier of discovery-to-delivery solutions for...

Learn more About VWR