RhoC protein-HIS Epitope, Rockland ImmunochemicalsSupplier: Rockland Immunochemical
75931-590EA 490.4 USD75931-590 75931-588
RhoC protein-HIS Epitope, Rockland Immunochemicals
Proteins and Peptides
RhoC control protein-HIS Epitope
- Control Protein
- PCA Assays
RhoC is member of the Rho family of small GTPases which promote reorganization of the actin cytoskeleton during cell morphogenesis and motility and regulate cell shape, attachment and motility. Active RhoC signals to its downstream effector ROCK which phosphorylates and activates LIM kinase that in turn phosphorylates cofilin inhibiting its actin-depolymerizing activity (1). Overexpression of RhoC is associated with tumor cell proliferation and metastasis while dominant-negative RhoC inhibits metastasis (2). Analysis of the phenotype of cells expressing dominant-negative RhoC indicates that RhoC is important in tumor cell invasion. RhoC Protein is ideal for investigators involved in Signaling Proteins, G-Proteins, Angiogenesis, Apoptosis/Autophagy, Cancer, Cardiovascular Disease, ERK/MAPK Pathway, Invasion/Metastasis, and Neurobiology research.
RhoC Protein is stored in 50mM sodium phosphate, pH 7.0, 300mM NaCl, 150mM imidazole, 0.1mM PMSF, 0.25mM DTT, 25% glycerol. RhoC Protein is suitable for use in Western Blot and Kinase Assay. Expect a band approximately ~23kDa on specific lysates or tissues. Specific conditions for reactivity should be optimized by the end user.