RGS1 protein-HIS Epitope, Rockland ImmunochemicalsSupplier: Rockland Immunochemical
75931-560EA 366.63 USD75931-560 75931-562
RGS1 protein-HIS Epitope, Rockland Immunochemicals
Proteins and Peptides
RGS1 control protein-HIS Epitope
- Control Protein
- PCA Assays
RGS1 is a member of the regulator of G-protein signaling family and attenuates the signaling activity of G-proteins. RGS1 binds to activated GTP-bound G alpha subunit and acts as a GTPase activating protein (GAP) thereby increasing the rate of conversion of GTP to GDP and terminating the signal (1). RGS1 is extensively up-regulated in renal cell carcinoma (RCC) tissues and melanoma. In melanoma, RGS1 expression is significantly correlated with increased tumor thickness, mitotic rate and presence of vascular involvement. Furthermore, there is significant association between increasing RGS1 expression and reduced relapse-free survival as well as disease-specific survival (DSS) survival (2). RGS1 Protein is ideal for investigators involved in Signaling Proteins, G-Proteins, AKT/PKB Pathway, Cancer, Cell Cycle, ERK/MAPK Pathway, Inflammation, JNK/SAPK Pathway, p38 Pathway, and PKA/PKC Pathway research.
RGS1 Protein is stored in 50mM sodium phosphate, pH 7.0, 300mM NaCl, 150mM imidazole, 0.1mM PMSF, 0.25mM DTT, 25% glycerol. RGS1 Protein is suitable for use in Western Blot. Expect a band approximately ~26kDa on specific lysates or tissues. Specific conditions for reactivity should be optimized by the end user.