PRMT5 protein-GST fusion, Rockland Immunochemicals

Supplier: Rockland Immunochemical
009-001-T05S 009-001-T05
75931-170EA 364.21 USD
75931-170 75931-172
PRMT5 protein-GST fusion, Rockland Immunochemicals
Proteins and Peptides
PRMT5 control protein-GST fusion

  • Control Protein
  • PCA Assays
  • ImmunoBlot

PRMT5 is a protein arginine methyltransferase and part of a 20S methyltransferase complex that modifies specific arginines to dimethylarginines in several spliceosomal Sm proteins (1). This modification targets Sm proteins to the survival of motor neurons (SMN) complex for assembly into small nuclear ribonucleoprotein core particles. MEP50 associates with PRMT5 in the 20S arginine methyltransferase complex in HeLa cells (2). Antibodies directed against MEP50 can reduce the arginine methyltransferase activity of the immunopurified complex toward Sm substrates. PRMT5-mediated transcriptional repression of reporter gene is dependent on MEP50. PRMT5 Protein is ideal for investigators involved in Signaling Proteins, Acetyl/Methyltransferase Proteins, Apoptosis/Autophagy, Cancer, Cell Cycle, and Neurobiology research.

PRMT5 Protein is stored in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol. PRMT5 Protein is suitable for use in Western Blot and Kinase Assay. Expect a band approximately ~96kDa on specific lysates or tissues. Specific conditions for reactivity should be optimized by the end user.
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