PRKAR1B protein-HIS Epitope, Rockland Immunochemicals

Supplier: Rockland Immunochemical
009-001-T04 009-001-T04S
75931-166EA 713.69 USD
75931-166 75931-164
PRKAR1B protein-HIS Epitope, Rockland Immunochemicals
Proteins and Peptides
PRKAR1B control protein-HIS Epitope

  • Control Protein
  • PCA Assays
  • ImmunoBlot

PRKAR1B is the type I-beta regulatory subunit of cyclic AMP-dependent protein kinase A (PKA) which is an essential enzyme in the cAMP signaling pathway. PKA holoenzyme is composed of 2 regulatory and 2 catalytic subunits and dissociates from the regulatory subunits upon binding of cAMP. PKA controls many biochemical events in the cell including regulation of metabolism, ion transport, and gene transcription. PKA undergoes a dramatic conformational change upon complex formation with the catalytic subunit (1). PRKAR1B subunits can dimerize through an N-terminal motif and this dimerization is necessary for binding to PKA anchoring proteins (AKAPs) and targeting of PKA to its site of action. PRKAR1B Protein is ideal for investigators involved in Signaling Proteins, Cellular Proteins, Apoptosis/Autophagy, Cardiovascular Disease, ERK/MAPK Pathway, Inflammation, Invasion/Metastasis, Metabolic Disorder, Neurobiology, NfkB Pathway, and PKA/PKC Pathway research.

PRKAR1B Protein is stored in 50mM sodium phosphate, pH 7.0, 300mM NaCl, 150mM imidazole, 0.1mM PMSF, 0.25mM DTT, 25% glycerol. PRKAR1B Protein is suitable for use in Western Blot. Expect a band approximately ~52kDa on specific lysates or tissues. Specific conditions for reactivity should be optimized by the end user.
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