PRKAR1A protein-HIS Epitope, Rockland Immunochemicals

Supplier: Rockland Immunochemical
009-001-T03S 009-001-T03
75931-160EA 364.21 USD
75931-160 75931-162
PRKAR1A protein-HIS Epitope, Rockland Immunochemicals
Proteins and Peptides
PRKAR1A control protein-HIS Epitope

  • Control Protein
  • PCA Assays
  • ImmunoBlot

PRKAR1A or the cAMP-dependent protein kinase regulatory subunit type I alpha, is part of the type 1 PKA holoenzyme. PRKAR1A is found to be a tissue-specific extinguisher that down-regulates the expression of seven liver genes in hepatoma x fibroblast hybrids (1). Mutations in PRKAR1A gene cause Carney complex (CNC) and PRKAR1A can fuse to the RET protooncogene by gene rearrangement and form the thyroid tumor-specific chimeric oncogene known as PTC2 (2). A nonconventional nuclear localization sequence (NLS) has been found for this protein which suggests a role in DNA replication via the protein serving as a nuclear transport protein for the second subunit of the Replication Factor C (RFC40). PRKAR1A Protein is ideal for investigators involved in Signaling Proteins, Cellular Proteins, Apoptosis/Autophagy, Cardiovascular Disease, ERK/MAPK Pathway, Inflammation, Invasion/Metastasis, Metabolic Disorder, Neurobiology, NfkB Pathway, and PKA/PKC Pathway research.

PRKAR1A Protein is stored in 50mM sodium phosphate, pH 7.0, 300mM NaCl, 150mM imidazole, 0.1mM PMSF, 0.25mM DTT, 25% glycerol. PRKAR1A Protein is suitable for use in Western Blot. Expect a band approximately ~51kDa on specific lysates or tissues. Specific conditions for reactivity should be optimized by the end user.
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