Hemoglobin S Control Peptide
- Control Peptide - Blocking Peptide
- PCA Assays
- ImmunoBlot
HbS peptide corresponds to the E6V mutant in the hemoglobin beta subunit. Functional adult hemoglobin (Hb) is a hetero tetramer composed of 2 alpha and 2 beta subunits (α2β2). Common isoform variants of hemoglobin include HbA, HbS, HbC, HbF, and HbA2. Hemoglobin S is the predominant hemoglobin in people with sickle cell disease. The alpha chain is normal. The disease-producing mutation exists in the beta chain, giving the molecule the structure, α2βS2. People who have one sickle mutant gene and one normal beta gene have sickle cell trait which is benign. Globin gene mutations affect the structure and expression levels of Hb. Sickle cell disease and the more benign sickle cell trait are observed in more than 100 million people globally. Perhaps the most significant mutation is the E6V in the beta subunit and the cause of SCD, but other relevant isoforms of Hb are observed. HbS peptide may be used as a control with anti-HbS antibody. This peptide is ideal for investigators involved in Cardiovascular and developmental biology research.
HbS peptide can be used as a control with the HbS antibody. Control peptide should be used at 1.0 µg per 1.0 µl of antiserum in per assay.
