Anti-CD45 Mouse Monoclonal Antibody (APC) [clone: 2D1]

Supplier: BioLegend
368511 368512 368511 368512
75781-328EA 84.22 USD
CA75781-328 75781-328 CA75781-330 75781-330
Anti-CD45 Mouse Monoclonal Antibody (APC) [clone: 2D1]
Antibodies
CD45 is a 180 to 240 kD single chain type I membrane glycoprotein also known as leukocyte common antigen (LCA) and T200. It is a tyrosine phosphatase expressed on the plasma membrane of all hematopoietic cells, except erythrocytes or platelets.

CD45 is a signaling molecule that regulates a variety of cellular processes including cell growth, differentiation, cell cycle, and oncogenic transformation. CD45 plays a critical role in T and B cell antigen receptor-mediated activation by dephosphorylating substrates including p56Lck, p59Fyn, and other Src family kinases. CD45 non-covalently associates with lymphocyte phosphatase-associated phosphoprotein (LPAP) on T and B lymphocytes. CD45 has been reported to bind galectin-1 and to be associated with several other cell surface antigens including CD1, CD2, CD3, and CD4.

Type: Primary
Antigen: CD45
Clonality: Monoclonal
Clone: 2D1
Conjugation: APC
Epitope:
Host: Mouse
Isotype: IgG1, ĸ
Reactivity: Human
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