CK-666
Synonyms:
2-Fluoro-N-[2-(2-methyl-1H-indol-3-yl)ethyl]-benzamide
A potent, selective and reversible inhibitor of ARP2/3 complex
CK-666 is a potent, selective and reversible inhibitor of ARP2/3 complex (actin related proteins 2 and 3) with an IC₅₀ = 4 µM for human ARP2/3. Blocks actin nucleation and radically alters lamellipodial actin architecture, suspended cell shape and the cell spreading process. CK-666 attenuates BBB dysfunction induced by methamphetamine. A key new tool for studying actin assembly and the diverse range of actin-related processes in normal and pathophysiology.
Formula:
C₁₈H₁₇FN₂O MW: 296.3 g/mol Storage Temperature: Freezer |
CAS Number:
442633-00-3 |
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