Plinabulin ≥95%

Synonyms: (3Z,6Z)-3-benzylidene-6-[(5-tert-butyl-1H-imidazol-4-yl)methylidene]piperazine-2,5-dioneNPI-2358

B2049-25 B2049-5
76269-494EA 531.21 USD
76269-494 76269-492
Plinabulin ≥95%
Plinabulin

Plinabulin (NPI-2358) is a vascular disrupting agent (VDA). Plinabulin binds to the colchicine binding site of β-tubulin preventing polymerization and disrupting the cytoplasmic microtubule network. It is also an antineoplastic agent that activates an immune response. Plinabulin induces dendritic cell maturation and cytokines interleukin-1β (IL-1β), IL-6, and IL-12 production, all of which are important in neutrophil survival.

Formula: C₁₉H₂₀N₄O₂ 
MW: 336,39 g/mol
CAS Number: 714272-27-2 
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