CBL0137 ≥98% (by HPLC)

Synonyms: 1,1'-[9-[2-[(1-methylethyl)amino]ethyl]-9H-carbazole-3,6-diyl]-bis-ethanoneCuraxin 137

B2036-5 B2036-25
76269-474EA 157.61 USD
76269-474 76269-476
CBL0137 ≥98% (by HPLC)
CBL0137

CBL0137 is a metabolically stable curaxin that activates p53 (EC₅₀ = 0.37 μM) and inhibits NF-κB (EC₅₀ = 0.47 μM). It functionally inactivates the facilitates chromatin transcription complex (FACT), driving the effects on p53 and NF-κB and promoting cancer cell death. CBL0137 has broad anticancer activity in mice when administered orally, eradicates drug-resistant cancer stem cells, and potentiates efficacy of gemcitabine (Cat. No.1759 in preclinical models of pancreatic cancer.

Formula: C₂₁H₂₄N₂O₂
MW: 336,4 g/mol
CAS Number: 1197996-80-7
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