PF-06409577  ≥98% (by HPLC)

Synonyms: 6-Chloro-5-(4-(1-hydroxycyclobutyl)phenyl)-1H-indole-3-carboxylic acid6-Chloro-5-[4-(1-hydroxycyclobutyl)phenyl]-1H-indole-3-carboxylic acid

B2033-5 B2033-25
76269-462EA 215.99 USD
76269-462 76269-464
PF-06409577  ≥98% (by HPLC)
PF-06409577 

PF-06409577 is a potent and selective allosteric activator of AMPK (EC₅₀ values are 7 and >40000 nM for AMPKα1β1γ1 and AMPKα1β2γ1, respectively). Displays minimal off-target effects on a panel of receptors, ion channels, PDEs and kinases. Shows efficacy in a preclinical model of diabetic nephropathy.

Formula: C₁₉H₁₆ClNO₃
MW: 341,79 g/mol
MDL Number: MFCD29917835
CAS Number: 1467057-23-3
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