AX-024 hydrochloride ≥98% (by HPLC)
Synonyms:
AX024
, 1-((4-(4-Fluorophenyl)-6-methoxy-2H-chromen-3-yl)methyl)pyrrolidine hydrochloride
AX-024 is a T cell receptor (TCR) inhibitor. An orally available inhibitor of the TCR-Nck interaction that selectively inhibits TCR-triggered T cell activation (IC₅₀ = 1 nM). By modulating TCR signaling, the inhibitor prevents the development of psoriasis and asthma. Additionally, it exerts a long-lasting therapeutic effect in a model of autoimmune encephalomyelitis.
Formula:
C₂₁H₂₂FNO₂.HCl MW: 375,86 g/mol |
MDL Number:
MFCD31628548 CAS Number: 1704801-24-0 |
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