Sapacitabine ≥98% (by HPLC)
Synonyms:
N-(1-((2R,3S,4S,5R)-3-cyano-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-2-oxo-1,2-dihydropyrimidin-4-yl)palmitamide
, CYC-682
, CS682
, CYC682
Sapacitabine is an orally bioavailable nucleoside analog prodrug that is potentially useful for treatment of hematologic malignancies and solid tumors. The active metabolite of sapacitabine, CNDAC (2'-C-cyano-2'-deoxy-1-β-D-arabino-pentofuranosylcytosine), displays the unique mechanism of action of causing single-strand breaks (SSBs) after incorporation into DNA, which are converted into double-strand breaks (DSBs) when cells enter a second S-phase.
Formula:
C₂₆H₄₂N₄O₅ MW: 490,64 g/mol |
CAS Number:
151823-14-2 |
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