Serabelisib ≥98% (by HPLC)
Supplier: BioVision
Synonyms:
INK1117
, TAK-117)
, MLN1117
, [6-(2-amino-5-benzoxazolyl)imidazo[1,2-a]pyridin-3-yl]-4-morpholinyl-methanone
, (6-(2-Aminobenzo[d]oxazol-5-yl)imidazo[1,2-a]pyridin-3-yl)(morpholino)methanone
Serabelisib is a potent inhibitor of phosphoinositide 3-kinase α (PI3Kα) that is selective for p110α in vitro (IC₅₀ = 15 nM for PI3Kα vs. >1 µM for other isoforms, as well as for mTOR). MLN1117 inhibits AKT phosphorylation and growth in PIK3CA mutant breast cancer cells with IC₅₀ values around 2 μM, yet has no effect on cells lacking PTEN.
Formula:
C₁₉H₁₇N₅O₃ MW: 363,34 g/mol |
MDL Number:
MFCD15146372 CAS Number: 1268454-23-4 |
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