Evofosamide ≥98%
Synonyms:
TH302
, N,N'-bis(2-bromoethyl)-
, Phosphorodiamidic acid
, TH-302
, 2-Bromo-N-[(2-bromoethylamino)-[(3-methyl-2-nitroimidazol-4-yl)methoxy]phosphoryl]ethanamine
, (1-methyl-2-nitro-1H-imidazol-5-yl)methyl ester
Evofosfamide (TH-302) is an anticancer agent that is a hypoxia-activated prodrug that is created by linking the hypoxia-seeking 2-nitroimidazole moiety to the cytotoxic bromo-isophosphoramide mustard (Br-IPM). When evofosfamide is delivered to hypoxic regions of tumors, the DNA cross-linking toxin, Br-IPM, is released leading to cell death.
Formula:
C₉H₁₆Br₂N₅O₄P MW: 449,04 g/mol |
MDL Number:
MFCD22420822 CAS Number: 918633-87-1 |
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