Zanamivir ≥98% (by HPLC)
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Warning
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Synonyms:
(2R,3R,4S)-3-Acetamido-4-guanidino-2-((1R,2R)-1,2,3-trihydroxypropyl)-3,4-dihydro-2H-pyran-6-carboxylic acid
, 4-Guanidino-2,4-dideoxy-2,3-dehydro-N-acetylneuraminic acid
, (2R,3R,4S)-3-acetamido-4-(diaminomethylideneamino)-2-[(1R,2R)-1,2,3-trihydroxypropyl]-3,4-dihydro-2H-pyran-6-carboxylic acid
, 4-Guanidino-Neu5Ac2en
Zanamivir is a potent and selective inhibitor of influenza A and B virus neuraminidases with IC₅₀ values of 0.95 nM and 2.7 nM, respectively. It interacts with a group of amino acids in the active site of neuraminidase, that are conserved in all influenza A and B strains. Zanamivir blocks the action of neuraminidase, which blocks the cleavage of sialic acid on the cell receptors, thus preventing release and spread of the newly formed virions.
Formula:
C₁₂H₂₀N₄O₇ MW: 332,31 g/mol |
MDL Number:
MFCD00866966 CAS Number: 139110-80-8 |
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