PNU-74654
Synonyms:
N'-((5-Methylfuran-2-yl)methylene)-2-phenoxybenzohydrazide
B1837-25
B1837-5
76269-678EA
145.93
USD
76269-678
76269-680
PNU-74654
PNU-74654
PNU-74654 is a β-catenin inhibitor (Kd = 450 nM), inhibiting its interaction with the transcription factor T cell factor 4 (Tcf4) resulting in disruption of the Wnt signaling pathway. Treatment of human adrenocortical cell lines with PNU-74654 significantly reduces expression of several Tcf/β-catenin target genes.
Formula:
C₁₉H₁₆N₂O₃ MW: 320.3419 g/mol |
MDL Number:
MFCD12912438 CAS Number: 113906-27-7 |
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