Dovitinib lactate ≥98% (by HPLC)
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Warning
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Synonyms:
Dovitinib lactate
, multitargeted receptor tyrosine kinase inhibitor
, Dovitinib
, CHIR 258
, 4-amino-5-fluoro-3-(6-(4-methylpiperazin-1-yl)-1H-benzo[d]imidazol-2-yl)quinolin-2(1H)-one 2-hydroxypropanoate hydrate
, TKI-258
, TKI258
, TKI 258
, CHIR258
, CHIR-258
Dovitinib (TKI258, CHIR258) is a multitargeted RTK inhibitor, mostly for class III (FLT3/c-Kit) with IC50 of 1 nM/2 nM, also potent to class IV (FGFR1/3) and class V (VEGFR1-4) RTKs with IC50 of 8-13 nM, less potent to InsR, EGFR, c-Met, EphA2, Tie2, IGF-1R and HER2 in cell-free assays.
Formula:
C₂₄H₂₉FN₆O₅ MW: 500,53 g/mol |
MDL Number:
MFCD16038433 CAS Number: 915769-50-5 |
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