GDC-0152 ≥98% (by HPLC)
Synonyms:
GDC 0152
, (S)-1-((S)-2-Cyclohexyl-2-((S)-2-(methylamino)propanamido)acetyl)-N-(4-phenyl-1,2,3-thiadiazol-5-yl)pyrrolidine-2-carboxamide
, GDC0152
, (2S)-1-[(2S)-2-cyclohexyl-2-[[(2S)-2-(methylamino)propanoyl]amino]acetyl]-N-(4-phenylthiadiazol-5-yl)pyrrolidine-2-carboxamide
GDC-0152 is a potent small molecule antagonist of XIAP-BIR3, ML-IAP-BIR3, cIAP1-BIR3 and cIAP2-BIR3 with Ki of 28 nM, 14 nM, 17 nM and 43 nM, respectively; less affinity shown to cIAP1-BIR2 and cIAP2-BIR2. Phase 1.
Formula:
C₂₅H₃₄N₆O₃S MW: 498,64 g/mol |
MDL Number:
MFCD26142660 CAS Number: 873652-48-3 |
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