Toceranib

Synonyms: SU 11654(Z)-5-((5-Fluoro-2-oxoindolin-3-ylidene)methyl)-2,4-dimethyl-N-(2-(pyrrolidin-1-yl)ethyl)-1H-pyrrole-3-carboxamide5-[(Z)-(5-Fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl]-2,4-dimethyl-N-[2-(1-pyrrolidinyl)ethyl]-1H-pyrrole-3-carboxamidePHA 291639

B1542-5 B1542-25
76265-450EA 671.3 USD
76265-450 76265-448
Toceranib
Toceranib

Toceranib is a potent, cell-permeable, ATP-competitive multi-targeted receptor tyrosine kinase inhibitor that is structurally related to Sunitinib (Cat. No. 2097). It potently inhibits signaling through VEGFR, FGFR, PDGFR, and Kit. Additionally, toceranib blocks the autophosphorylation of both wild type and mutant forms of Kit in response to stem cell factor, resulting in cell death. It is active in vivo and is commonly used against solid tumors in dogs.

Formula: C₂₂H₂₅FN₄O₂
MW: 396.46 g/mol
Storage Temperature: Freezer
MDL Number: MFCD16038046
CAS Number: 356068-94-5
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