VR23
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Warning
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Synonyms:
7-chloro-4-(4-((2,4-dinitrophenyl)sulphonyl)piperazin-1-yl)quinoline
, 7-chloro-4-(4-((2,4-dinitrophenyl)sulfonyl)piperazin-1-yl)quinoline
VR23 is a potent and selective inhibitor of trypsin-like proteasomes (IC₅₀ = 1 nmol/L), chymotrypsin-like proteasomes (IC₅₀ = 50-100 nmol/L), and caspase-like proteasomes (IC₅₀ = 3 μmol/L). The main molecular target of VR23 was β2 of the 20S proteasome catalytic subunit. It also deregulates the activity of cyclin E and other centrosomal proteins, resulting in the induction of multiple centrosome amplification, abnormal spindle formation, uneven cytokinesis, irreversible mitotic arrest, and eventually apoptosis that is specific to cancer cells.
Formula:
C₁₉H₁₆ClN₅O₆S MW: 477.88 g/mol Storage Temperature: Freezer |
MDL Number:
MFCD28502093 CAS Number: 1624602-30-7 |
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About VWR
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