VR23

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Synonyms: 7-chloro-4-(4-((2,4-dinitrophenyl)sulphonyl)piperazin-1-yl)quinoline7-chloro-4-(4-((2,4-dinitrophenyl)sulfonyl)piperazin-1-yl)quinoline

B1515-5 B1515-25
76265-194EA 157.56 USD
76265-194 76265-196
VR23
VR23

VR23 is a potent and selective inhibitor of trypsin-like proteasomes (IC₅₀ = 1 nmol/L), chymotrypsin-like proteasomes (IC₅₀ = 50-100 nmol/L), and caspase-like proteasomes (IC₅₀ = 3 μmol/L). The main molecular target of VR23 was β2 of the 20S proteasome catalytic subunit. It also deregulates the activity of cyclin E and other centrosomal proteins, resulting in the induction of multiple centrosome amplification, abnormal spindle formation, uneven cytokinesis, irreversible mitotic arrest, and eventually apoptosis that is specific to cancer cells.

Formula: C₁₉H₁₆ClN₅O₆S
MW: 477.88 g/mol
Storage Temperature: Freezer
MDL Number: MFCD28502093
CAS Number: 1624602-30-7
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