Congo red, Ultra Pure Grade

Supplier: Anaspec Inc
Danger

Synonyms: Disodium 3,3'-[[1,1'-biphenyl]-4,4'-diylbis(azo)]bis(4-aminonaphthalene-1-sulfonate)Sodium 3,3'-([1,1'-biphenyl]-4,4'-diylbis(diazene-2,1-diyl))bis(4-aminonaphthalene-1-sulphonate)Direct Red 28Sodium 3,3'-([1,1'-biphenyl]-4,4'-diylbis(diazene-2,1-diyl))bis(4-aminonaphthalene-1-sulfonate)Disodium 3,3'-[[1,1'-biphenyl]-4,4'-diylbis(azo)]bis(4-aminonaphthalene-1-sulphonate)CI 22120

AS-83016
103011-118EA 230.92 USD
103011-118
Congo red, Ultra Pure Grade
Congo Red

  • Storage: -20°C desiccated and protected from light
  • Spectral Properties: Abs/Em = 497/NA nm
  • Solvent System: water


Early diagnosis and classification of amyloid deposition and differentiation from other glomerular fibrillar deposits rely on routine Congo red (CR) histochemistry. CR binding, monitored by characteristic yellow-green birefringence under crossed polarization has been used as a diagnostic test for the presence of amyloid in tissue sections for several decades. This assay is also widely used for the characterization of in vitro amyloid fibrils. CR is sandwiched between two protein molecules causing protein oligomerization. Congo red fluorescence (CRF) is an alternative method based on examination of the CR-stained section by ultraviolet (UV) light. Congo red fluorescence is simple to perform and more pronounced, therefore easier to evaluate than CR in bright light. Congo red, when combined with immunohistochemistry, is still visible under UV whereas CR is masked in bright light. Although not widely used, the CRF method for detecting amyloid is simple to use with a high specificity and sensitivity, and may be applied successfully to frozen sections.

Formula: C₃₂H₂₂N₆Na₂O₆S₂
MW: 696.67 g/mol
Melting Pt: > 360 °C
Storage Temperature: Ambient
MDL Number: MFCD00004028
CAS Number: 573-58-0
EINECS: 209-358-4

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