Y-27632, InSolution™, Calbiochem®

Supplier: MilliporeSigma

Synonyms: (R)-(+)-trans-N-(4-Pyridyl)-4-(1-aminoethyl)-cyclohexanecarboxamide, 2HCl(R)-(+)-trans-4-(1-Aminoethyl)-N-(4-Pyridyl)cyclohexanecarboxamide dihydrochlorideROCK InhibitorY-27632 dihydrochlorideRho Kinase Inhibitor VI

Packaged under inert gas.

80512-706EA 229.81 USD
Y-27632, InSolution™, Calbiochem®

A 5 mM (500 µg/296 µl) solution of Y-27632 (Cat. No. 688000) in H₂O.

A highly potent, cell-permeable, selective inhibitor of Rho-associated protein kinase (Ki = 140 nM for p160ROCK (ROCK-I). Also inhibits ROCK-II with almost equal potency. Inhibition is achieved by competing with ATP for binding to the catalytic site. Exhibits 10- to 50-fold lower affinity for PKCε than p160ROCK. Does not affect the activity of p21-activated protein kinase (PAK) even at high concentrations (~100 mM). Also acts as a potent inhibitor of agonist-induced Ca2+ sensitization of myosin phosphorylation and smooth muscle contractions (IC50 = 700 nM for phenylephrine-induced contractions in aortic strips).

Formula: C₁₄H₂₁N₃O·2HCl
MW: 320.26 g/mol
Storage Temperature: Freezer
MDL Number: MFCD03490488
CAS Number: 146986-50-7

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Specification Test Results

Primary Target p160ROCK
Primary Target IC50 700 nM against phenylephrine-induced contractions in aortic strips
Primary Target Ki 140 nM for p160ROCK (ROCK-I)
Purity ≥95% by HPLC

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