Anti-Phospho(409/410)-TDP43 Mouse Monoclonal Antibody [Clone: 1A2C1]

Supplier: Proteintech
66318-1-IG-100UL
75831-750EA 452.35 USD
75831-750
Anti-Phospho(409/410)-TDP43 Mouse Monoclonal Antibody [Clone: 1A2C1]
Antibodies
This antibody is a phospho-dependent monoclonal antibody specifically recognizing phospho-TDP43 (409/410). It does not react with native TDP-43.

  • Positive WB detected in: Ethacrynic acid treated HeLa cells, C6 cells, HEK-293 cells, Human placenta tissue, Neuro-2a cells
  • Recommended dilution for WB: 1:500 - 1:2000

The TARDBP gene encodes the TDP-43 protein, initially found to repress HIV-1 transcription by binding TAR DNA. TDP-43 has since been shown to bind RNA as well as DNA, and have multiple functions in transcriptional repression, translational regulation and pre-mRNA splicing.

It is reported to regulate alternate splicing of the CTFR gene. The hyperphosphorylated, ubiquitinated and/or cleaved forms of TDP-43, collectively known as pathological TDP-43, play a major role in the disease mechanisms of ubiquitin-positive, tau- and alpha-synuclein-negative frontotemporal dementia (FTLD-U) and in amyotrophic lateral sclerosis (ALS).

Type: Primary
Antigen: TARDBP
Clonality: Monoclonal
Clone: 1A2C1
Conjugation:
Epitope:
Host: Mouse
Isotype: IgG1
Reactivity: Human, Mouse, Rat
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