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Anti-Phospho(409/410)-TDP43 Mouse Monoclonal Antibody [Clone: 1A2C1]

Supplier: Proteintech
66318-1-IG
This antibody is a phospho-dependent monoclonal antibody specifically recognizing phospho-TDP43 (409/410). It does not react with native TDP-43.

  • Positive WB detected in: Ethacrynic acid treated HeLa cells, C6 cells, HEK-293 cells, Human placenta tissue, Neuro-2a cells
  • Recommended dilution for WB: 1:500 - 1:2000

The TARDBP gene encodes the TDP-43 protein, initially found to repress HIV-1 transcription by binding TAR DNA. TDP-43 has since been shown to bind RNA as well as DNA, and have multiple functions in transcriptional repression, translational regulation and pre-mRNA splicing.

It is reported to regulate alternate splicing of the CTFR gene. The hyperphosphorylated, ubiquitinated and/or cleaved forms of TDP-43, collectively known as pathological TDP-43, play a major role in the disease mechanisms of ubiquitin-positive, tau- and alpha-synuclein-negative frontotemporal dementia (FTLD-U) and in amyotrophic lateral sclerosis (ALS).

Type: Primary
Antigen: TARDBP
Clonality: Monoclonal
Clone: 1A2C1
Conjugation:
Epitope:
Host: Mouse
Isotype: IgG1
Reactivity: Human, Mouse, Rat




 

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Size Supplier No. VWR Catalog Number Unit Price Quantity
1 g 66318-1-IG 75831-750 Each (150µl) Retrieving Restricted

Temperature sensitive This Item is temperature-controlled and may have specific temperature and storage requirements for shipping/delivery.

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SPECIFICATIONS

Antigen Symbol TDP43
Reactivity Mouse, Human, Rat
Clonality Monoclonal
Antibody Type Primary
Clone 1A2C1
Isotype IgG1
Western Blot Yes
ELISA Yes
Antigen Synonyms TAR DNA binding protein, TDP 43, TAR DNA binding protein 43, TDP43, TARDBP, Phospho(409/410)-TDP43, ALS10
Gene ID 23435
Concentration 225 μg/150 μl
Immunogen Peptide
Molecular Weight 43 kDa
Purification Protein G purification
Storage Buffer PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage Temperature -20 °C
Source Mouse
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