Phorbol 12-myristate 13-acetate (PMA)
Supplier: Promega Corporation
|
Warning
|
Synonyms:
TPA
, 12-O-Tetradecanoylphorbol 13-acetate, 4β,9α,12β,13α,20-Pentahydroxytiglia-1,6-dien-3-one 12-tetradecanoate 13-acetate
Phorbol 12-myristate 13-acetate (PMA) is a specific activator of group A (α, βI, βII, γ) and group B (δ, ε, η, θ) Protein Kinase Cs (PKCs) (in the 1–100nM range).
- Specific activator of group A (α, βI, βII, γ) and group B (δ, ε, η, θ) Protein Kinase Cs
- Supplied as a dried material
Phorbol esters, such as PMA, affect PKCs by mimicking diacylglycerol, a natural ligand and activator of PKCs. PMA is an effective skin irritant and potent tumor promoter in mice. A common alternative name for PMA is 12-O-tetradecanoylphorbol 13-acetate (TPA). The chemical identity and purity of PMA are confirmed by proton NMR.
Supplied as a dried material. Resuspend 5mg in 1.62ml of DMSO to produce a stock solution of 5mM.
Storage: -30°C to -10°C
|
Formula:
C₃₆H₅₆O₈ MW: 616.836 g/mol Storage Temperature: Freezer |
MDL Number:
MFCD00036736 CAS Number: 16561-29-8 |
Learn more
About VWR
Avantor is a vertically integrated, global supplier of discovery-to-delivery solutions for...