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Anti-SUMO2 Mouse Monoclonal Antibody (CF405S) [clone: Clone SUMO2/1199]

Supplier: Biotium
BNC041199-500 BNC041199-100
The small ubiquitin-related modifier (SUMO) proteins, which include SUMO-1, 2 and 3, belong to the ubiquitin-like protein family. Like ubiquitin, the SUMO proteins are synthesized as precursor proteins that undergo processing before conjugation to target proteins. Also, both utilize the E1, E2 and E3 cascade enzymes for conjugation. However, SUMO and ubiquitin differ with respect to targeting. Ubiquitination predominantly targets proteins for degradation, whereas sumoylation targets proteins to a variety of cellular processing, including nuclear transport, transcriptional regulation, apoptosis and protein stability. The unconjugated SUMO-1, 2 and 3 proteins localize to the nuclear membrane, nuclear bodies and cytoplasm, respectively. SUMO-1 utilizes Ubc9 for conjugation to several target proteins, which include MDM2, p53, PML and RanGap1. SUMO-2 and 3 contribute to a greater percentage of protein modification than does SUMO-1 and unlike SUMO-1, they can form polymeric chains. In addition, SUMO-3 regulates beta-Amyloid generation and may be critical in the onset or progression of Alzheimer s disease.

CF® dyes are Biotium's next-generation fluorescent dyes. CF®405S is a blue fluorescent dye (Ex/Em 404/431 nm) with superior brightness compared to other blue dyes; it is also compatible with super-resolution imaging by SIM. Note: Conjugates of blue fluorescent dyes are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Type: Primary
Antigen: SUMO2
Clonality: Monoclonal
Clone: Clone SUMO2/1199
Conjugation: CF405S
Epitope:
Host: Mouse
Isotype: IgG1
Reactivity: Human, Rat




 

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Size Supplier No. VWR Catalog Number Unit Price Quantity
100 μL BNC041199-100 75974-528 Each (100µl) Retrieving Restricted

Temperature sensitive This Item is temperature-controlled and may have specific temperature and storage requirements for shipping/delivery.

500 μL BNC041199-500 75974-530 Each (500µl) Retrieving Restricted

Temperature sensitive This Item is temperature-controlled and may have specific temperature and storage requirements for shipping/delivery.

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SPECIFICATIONS

Antigen Symbol SUMO2
Antigen Name SUMO-2
Reactivity Human, Rat Rat, Human
Conjugation CF™ 405S
Clonality Monoclonal
Antibody Type Primary
Clone SUMO2/1199
Host Mouse
Isotype IgG1
ImmunoChemistry Yes
ImmunoFluorescence Yes
Gene ID Unigene ID: 474005
Concentration 0.1 mg/mL
Storage Buffer PBS/0.1% BSA/0.05% azide
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