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Anti-FBXO5 Mouse Monoclonal Antibody (CF405M) [clone: Clone EMI1/1176]

Supplier: Biotium
BNC051176-500 BNC051176-100
This antibody recognizes a 56 kDa protein, which is identified as Early Mitotic Inhibitor-1 (EMI1). It regulates mitosis by inhibiting the anaphase promoting complex/cyclosome (APC). Emi1 is a conserved F box protein containing a zinc-binding region essential for APC inhibition. The Emi1 protein functions to promote cyclin A accumulation and S phase entry in somatic cells by inhibiting the APC complex. At the G1-S transition, Emi1 is transcriptionally induced by the E2F transcription factor. Emi1 overexpression accelerates S-phase entry and can override a G1 block caused by overexpression of Cdh1 or the E2F-inhibitor p105 retinoblastoma protein (pRb). Depleting cells of Emi1 through RNA interference prevents accumulation of cyclin A and inhibits S phase entry.

CF® dyes are Biotium's next-generation fluorescent dyes. CF®405M is a blue fluorescent dye (Ex/Em 408/452 nm) with superior brightness and photostability compared to other blue dyes; it is also compatible with super-resolution imaging by SIM. Note: Conjugates of blue fluorescent dyes are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Type: Primary
Antigen: FBXO5
Clonality: Monoclonal
Clone: Clone EMI1/1176
Conjugation: CF405M
Epitope:
Host: Mouse
Isotype: IgG2b, kappa
Reactivity: Human




 

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Size Supplier No. VWR Catalog Number Unit Price Quantity
100 μL BNC051176-100 75925-716 Each (100µl) Retrieving Restricted

Temperature sensitive This Item is temperature-controlled and may have specific temperature and storage requirements for shipping/delivery.

500 μL BNC051176-500 75925-718 Each (500µl) Retrieving Restricted

Temperature sensitive This Item is temperature-controlled and may have specific temperature and storage requirements for shipping/delivery.

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SPECIFICATIONS

Antigen Symbol FBXO5
Antigen Name EMI1
Reactivity Human
Conjugation CF™ 405M
Clonality Monoclonal
Antibody Type Primary
Clone EMI1/1176
Host Mouse
Isotype IgG2b, kappa
Western Blot Yes
ImmunoChemistry Yes
ImmunoFluorescence Yes
Gene ID Unigene ID: 520506
Concentration 0.1 mg/mL
Storage Buffer PBS/0.1% BSA/0.05% azide
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