Anti-PTH Mouse Monoclonal Antibody (Biotin) [clone: PTH/1174]

Supplier: Biotium

BNCB1174-500 BNCB1174-100
75973-402EA 547.44 USD
75973-402 75973-400
Anti-PTH Mouse Monoclonal Antibody (Biotin) [clone: PTH/1174]
Antibodies
The epitope of this MAb maps in the C-terminus of PTH, a hormone produced by the parathyroid gland that regulates the concentration of calcium and phosphorus in extracellular fluid. This hormone elevates blood Ca2 levels by dissolving the salts in bone and preventing their renal excretion.It is produced in the parathyroid gland as an 84 amino acid single chain polypeptide. It can also be secreted as N-terminal truncated fragments or C-terminal fragments after intracellular degradation, as in case of hypercalcemia. Defects in this gene are a cause of familial isolated hypoparathyroidism (FIH); also called autosomal dominant hypoparathyroidism or autosomal dominant hypocalcemia. FIH is characterized by hypocalcemia and hyperphosphatemia due to inadequate secretion of parathyroid hormone. Symptoms are seizures, tetany and cramps. FIH exist both as autosomal dominant and recessive forms of hypoparathyroidism.

Type: Primary
Antigen: PTH
Clonality: Monoclonal
Clone: Clone PTH/1174
Conjugation: Biotin
Epitope:
Host: Mouse
Isotype: IgG2b, kappa
Reactivity: Human
Order Now

Learn more

About VWR

Avantor is a vertically integrated, global supplier of discovery-to-delivery solutions for...

Learn more About VWR