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Anti-TNF Mouse Monoclonal Antibody (CF680) [clone: Clone TNFA/1172]

Supplier: Biotium
BNC801172-500 BNC801172-100
This MAb recognizes human 17-26 kDa protein, which is identified as cytokine TNF-alpha (Tumor Necrosis Factor-alpha). TNF-alpha can be expressed as a 17 kDa free molecule, or as a 26 kDa membrane protein. TNF-alpha is a protein secreted by lipopolysaccharide-stimulated macrophages, and causes tumor necrosis when injected into tumor bearing mice. TNF alpha causes cytolysis of certain transformed cells, being synergistic with interferon gamma in its cytotoxicity. Although it has little effect on many cultured normal human cells, TNF alpha appears to be directly toxic to vascular endothelial cells. Other actions of TNF alpha include stimulating growth of human fibroblasts and other cell lines, activating polymorphonuclear neutrophils and osteoclasts, and induction of interleukin 1, prostaglandin E2 and collagenase production. TNF alpha is currently being evaluated in treatment of certain cancers and AIDS Related Complex.

CF® dyes are Biotium's next-generation fluorescent dyes. CF®680 is a near-infrared fluorescent dye (Ex/Em 681/698 nm). It yields the brightest conjugates among spectrally similar dyes, and is validated in super-resolution imaging by STORM.

Type: Primary
Antigen: TNF
Clonality: Monoclonal
Clone: Clone TNFA/1172
Conjugation: CF680
Epitope:
Host: Mouse
Isotype: IgG1, kappa
Reactivity: Human, Rat




 

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Size Supplier No. VWR Catalog Number Unit Price Quantity
100 μL BNC801172-100 75977-268 Each (100µl) Retrieving Restricted

Temperature sensitive This Item is temperature-controlled and may have specific temperature and storage requirements for shipping/delivery.

500 μL BNC801172-500 75977-270 Each (500µl) Retrieving Restricted

Temperature sensitive This Item is temperature-controlled and may have specific temperature and storage requirements for shipping/delivery.

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SPECIFICATIONS

Antigen Symbol TNF
Antigen Name TNF alpha
Reactivity Rat, Human Human, Rat
Conjugation CF™ 680
Clonality Monoclonal
Antibody Type Primary
Clone TNFA/1172
Host Mouse
Isotype IgG1, kappa
ImmunoChemistry Yes
ImmunoFluorescence Yes
Gene ID Unigene ID: 241570
Concentration 0.1 mg/mL
Storage Buffer PBS/0.1% BSA/0.05% azide
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