Anti-HLA-B Mouse Monoclonal Antibody (PerCP) [clone: JOAN-1]

BNCP1005-250
75950-884EA 370.56 USD
75950-884
Anti-HLA-B Mouse Monoclonal Antibody (PerCP) [clone: JOAN-1]
Antibodies
HLA-B belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon 1 encodes the leader peptide, exon 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Hundreds of HLA-B alleles have been described.

Type: Primary
Antigen: HLA-B
Clonality: Monoclonal
Clone: Clone JOAN-1
Conjugation: PerCP
Epitope:
Host: Mouse
Isotype: IgG3 kappa
Reactivity: Human
Order Now

Learn more

About VWR

Avantor is a vertically integrated, global supplier of discovery-to-delivery solutions for...

Learn more About VWR