Anti-HLA-B Mouse Monoclonal Antibody (CF488A) [clone: JOAN-1]

Supplier: Biotium

BNC881005-500 BNC881005-100
75950-836EA 547.44 USD
75950-836 75950-834
Anti-HLA-B Mouse Monoclonal Antibody (CF488A) [clone: JOAN-1]
Antibodies
HLA-B belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon 1 encodes the leader peptide, exon 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Hundreds of HLA-B alleles have been described.

CF® dyes are Biotium's next-generation fluorescent dyes. CF®488A is a green fluorescent dye (Ex/Em 490/515 nm) with excellent brightness and photostability. The dye is minimally charged for less non-specific binding. CF®488A also is compatible with super-resolution imaging by TIRF.

Type: Primary
Antigen: HLA-B
Clonality: Monoclonal
Clone: Clone JOAN-1
Conjugation: CF488A
Epitope:
Host: Mouse
Isotype: IgG3 kappa
Reactivity: Human
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