Anti-CYCS Mouse Monoclonal Antibody (CF488A) [clone: CTC05]

Supplier: Biotium

BNC880887-100 BNC880887-500
75923-834EA 547.44 USD
75923-834 75923-832
Anti-CYCS Mouse Monoclonal Antibody (CF488A) [clone: CTC05]
Antibodies
Cytochrome c is a well-characterized mobile electron transport protein that is essential to energy conversion in all aerobic organisms. In mammalian cells, this highly conserved protein is normally localized to the mitochondrial inter-membrane space. More recent studies have identified cytosolic Cytochrome c as a factor necessary for activation of apoptosis. During apoptosis, Cytochrome c is trans-located from the mitochondrial membrane to the cytosol, where it is required for activation of caspase-3 (CPP32). Overexpression of Bcl-2 has been shown to prevent the translocation of Cytochrome c, thereby blocking the apoptotic process. Overexpression of Bax has been shown to induce the release of Cytochrome c and to induce cell death. The release of Cytochrome c from the mitochondria is thought to trigger an apoptotic cascade, whereby Apaf-1 binds to Apaf-3 (caspase-9) in a Cytochrome c-dependent manner, leading to caspase-9 cleavage of caspase-3.

CF® dyes are Biotium's next-generation fluorescent dyes. CF®488A is a green fluorescent dye (Ex/Em 490/515 nm) with excellent brightness and photostability. The dye is minimally charged for less non-specific binding. CF®488A also is compatible with super-resolution imaging by TIRF.

Type: Primary
Antigen: CYCS
Clonality: Monoclonal
Clone: CTC05
Conjugation: CF488A
Epitope:
Host: Mouse
Reactivity: Dog, Drosophila, Frog, Horse, Human, Mouse, Pigeon, Rat
Isotype: IgG2b, kappa
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