Anti-CYCS Mouse Monoclonal Antibody (CF770) [clone: CTC05]

BNC700887-500 BNC700887-100
75923-866EA 494 USD
75923-866 75923-864
Anti-CYCS Mouse Monoclonal Antibody (CF770) [clone: CTC05]
Antibodies
Cytochrome c is a well-characterized mobile electron transport protein that is essential to energy conversion in all aerobic organisms. In mammalian cells, this highly conserved protein is normally localized to the mitochondrial inter-membrane space. More recent studies have identified cytosolic Cytochrome c as a factor necessary for activation of apoptosis. During apoptosis, Cytochrome c is trans-located from the mitochondrial membrane to the cytosol, where it is required for activation of caspase-3 (CPP32). Overexpression of Bcl-2 has been shown to prevent the translocation of Cytochrome c, thereby blocking the apoptotic process. Overexpression of Bax has been shown to induce the release of Cytochrome c and to induce cell death. The release of Cytochrome c from the mitochondria is thought to trigger an apoptotic cascade, whereby Apaf-1 binds to Apaf-3 (caspase-9) in a Cytochrome c-dependent manner, leading to caspase-9 cleavage of caspase-3.

CF® dyes are Biotium's next-generation fluorescent dyes. CF®770 is a near-infrared fluorescent dye (Ex/Em 770/797 nm) with exceptional brightness for in vivo imaging or near-IR western blotting.

Type: Primary
Antigen: CYCS
Clonality: Monoclonal
Clone: CTC05
Conjugation: CF770
Epitope:
Host: Mouse
Reactivity: Dog, Drosophila, Frog, Horse, Human, Mouse, Pigeon, Rat
Isotype: IgG2b, kappa
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