Anti-TNF Mouse Monoclonal Antibody (HRP) [clone: 4C6-H8]

BNCH0866-500 BNCH0866-100
75976-728EA 185.18 USD
75976-728 75976-730
Anti-TNF Mouse Monoclonal Antibody (HRP) [clone: 4C6-H8]
Antibodies
Tumor Necrosis Factor Alpha (TNF alpha) is a protein secreted by lipopolysaccharide-stimulated macrophages, and causes tumor necrosis when injected into tumor bearing mice. TNF alpha is believed to mediate pathogenic shock and tissue injury associated with endotoxemia. TNF alpha exists as a multimer of two, three, or five non-covalently linked units, but shows a single 17 kDa band following SDS PAGE under non-reducing conditions. TNF alpha is closely related to the 25 kDa protein Tumor Necrosis Factor beta (lymphotoxin), sharing the same receptors and cellular actions. TNF alpha causes cytolysis of certain transformed cells, being synergistic with interferon gamma in its cytotoxicity. Although it has little effect on many cultured normal human cells, TNF alpha appears to be directly toxic to vascular endothelial cells. Other actions of TNF alpha include stimulating growth of human fibroblasts and other cell lines, activating polymorphonuclear neutrophils and osteoclasts, and induction of interleukin 1, prostaglandin E2 and collagenase production. TNF alpha is currently being evaluated in treatment of certain cancers and AIDS Related Complex.

Type: Primary
Antigen: TNF
Clonality: Monoclonal
Clone: Clone 4C6-H8
Conjugation: HRP
Epitope:
Host: Mouse
Isotype: IgM, kappa
Reactivity: Cat, Dog, Human, Mouse, Rabbit, Rat, Zebrafish
Order Now

Learn more

About VWR

Avantor is a vertically integrated, global supplier of discovery-to-delivery solutions for...

Learn more About VWR