Anti-PTPRC Mouse Monoclonal Antibody (CF543) [clone: 2B11 PD7/26]

BNC430745-100 BNC430745-500
75914-720EA 179 USD
75914-720 75914-722
Anti-PTPRC Mouse Monoclonal Antibody (CF543) [clone: 2B11 PD7/26]
Antibodies
This antibody recognizes the CD45 leukocyte common antigen (LCA) family which comprises at least four isoforms of membrane glycoproteins (220, 205, 190, 180 kDa) expressed on hematopoietic cell lines but absent on non-hematopoietic cell lines, normal and malignant non-hematopoietic tissues. The intracellular portions of these molecules have protein phosphatase activity and are involved in regulation of transmembrane signals. Antibody to CD45 is useful in differential diagnosis of lymphoid tumors from non-hematopoietic undifferentiated neoplasms. A positive result with this MAb is highly indicative of lymphoid or myeloid origin. Certain types of lymphoid neoplasms may lack CD45 (Hodgkin lymphoma, some T-cell lymphomas, and some leukemias) so its absence does not rule out a hematolymphoid tumor. This antibody is expressed almost exclusively by cells of hematopoietic lineage and is present in most benign and malignant lymphocytes as well as plasma cell precursors.

CF® dyes are Biotium's next-generation fluorescent dyes. CF®543 is an orange fluorescent dye (Ex/Em 541/560 nm) designed for the 543 nm laser line. It yields the brightest conjugates among spectrally similar dyes.

Type: Primary
Antigen: PTPRC
Clonality: Monoclonal
Clone: Clone 2B11 PD7/26
Conjugation: CF543
Epitope:
Host: Mouse
Isotype: IgG's
Reactivity: Dog, Human
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