Anti-PAX6 Mouse Monoclonal Antibody [clone: PAX6/498]

Supplier: Biotium

BNUB0498-500 BNUB0498-100
75968-198EA 231.53 USD
75968-198 75968-200
Anti-PAX6 Mouse Monoclonal Antibody [clone: PAX6/498]
Antibodies
Pax genes contain paired domains with strong homology to genes in Drosophila, which are involved in programming early development. Lesions in the Pax-6 gene account for most cases of aniridia, a congenital malformation of the eye, chiefly characterized by iris hypoplasia, which can cause blindness. Pax-6 is involved in other anterior segment malformations besides aniridia, such as Peters anomaly, a major error in the embryonic development of the eye with corneal clouding with variable iridolenticulocorneal adhesions. The Pax-6 gene encodes a transcriptional regulator that recognizes target genes through its paired-type DNA-binding domain. The paired domain is composed of two distinct DNA-binding subdomains, the amino-terminal subdomain and the carboxy-terminal subdomain, which bind respective consensus DNA sequences. The human Pax-6 gene produces two alternatively spliced isoforms that have the distinct structure of the paired domain.

Type: Primary
Antigen: PAX6
Clonality: Monoclonal
Clone: Clone PAX6/498
Conjugation: Unconjugated
Epitope:
Host: Mouse
Isotype: IgG1, kappa
Reactivity: Chicken, Human, Mouse, Rat
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