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Anti-SUMO2 & SUMO3 Mouse Monoclonal Antibody (CF405M) [clone: Clone SM23/496]

Supplier: Biotium
BNC050496-100 BNC050496-500
This MAb reacts with both SUMO-2 and SUMO-3. The small ubiquitin-related modifier (SUMO) proteins, which include SUMO-1, 2 and 3, belong to the ubiquitin-like protein family. Like ubiquitin, the SUMO proteins are synthesized as precursor proteins that undergo processing before conjugation to target proteins. Also, both utilize the E1, E2 and E3 cascade enzymes for conjugation. However, SUMO and ubiquitin differ with respect to targeting. Ubiquitination predominantly targets proteins for degradation, whereas sumoylation targets proteins to a variety of cellular processing, including nuclear transport, transcriptional regulation, apoptosis and protein stability. The unconjugated SUMO-1, 2 and 3 proteins localize to the nuclear membrane, nuclear bodies and cytoplasm, respectively. SUMO-1 utilizes Ubc9 for conjugation to several target proteins, which include MDM2, p53, PML and RanGap1. SUMO-2 and 3 contribute to a greater percentage of protein modification than does SUMO-1 and unlike SUMO-1, they can form polymeric chains. In addition, SUMO-3 regulates beta-Amyloid generation and may be critical in the onset or progression of Alzheimer’s disease.

Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.CF® dyes are Biotium's next-generation fluorescent dyes. CF®405M is a blue fluorescent dye (Ex/Em 408/452 nm) with superior brightness and photostability compared to other blue dyes; it is also compatible with super-resolution imaging by SIM. Note: Conjugates of blue fluorescent dyes are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Type: Primary
Antigen: SUMO2 & SUMO3
Clonality: Monoclonal
Clone: Clone SM23/496
Conjugation: CF405M
Epitope:
Host: Mouse
Isotype: IgG1, kappa
Reactivity: Human




 

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Size Supplier No. VWR Catalog Number Unit Price Quantity
100 μL BNC050496-100 75974-576 Each (100µl) Retrieving Restricted

Temperature sensitive This Item is temperature-controlled and may have specific temperature and storage requirements for shipping/delivery.

500 μL BNC050496-500 75974-578 Each (500µl) Retrieving Restricted

Temperature sensitive This Item is temperature-controlled and may have specific temperature and storage requirements for shipping/delivery.

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SPECIFICATIONS

Antigen Symbol SUMO2 & SUMO3
Antigen Name SUMO-2/3
Reactivity Human
Conjugation CF™ 405M
Clonality Monoclonal
Antibody Type Primary
Clone SM23/496
Host Mouse
Isotype IgG1, kappa
Western Blot Yes
ImmunoFluorescence Yes
Concentration 0.1 mg/mL
Storage Buffer PBS/0.1% BSA/0.05% azide
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