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Anti-TOP1MT Mouse Monoclonal Antibody (Unconjugated, BSA-and azide-free) [clone: Clone TOP1MT/488]

Supplier: Biotium
DNA topoisomerases are nuclear enzymes that regulate the topological structure of DNA in eukaryotic cells by transiently breaking and rejoining DNA strands. Due to their roles in DNA replication, recombination, and transcription, DNA topoisomerases have been identified as targets of numerous anticancer drugs. Mitochondrial Topo I (DNA topoisomerase I, mitochondrial) is a 601 amino acid protein that primarily acts to relieve DNA strain that may occur during duplication of mitochondrial DNA. As a type IB topoisomerase, mitochondrial Topo I requires a divalent metal, either, calcium or magnesium, as well as an alkaline pH for optimal activity.

Type: Primary
Antigen: TOP1MT
Clonality: Monoclonal
Clone: Clone TOP1MT/488
Conjugation: Unconjugated, BSA-and azide-free
Host: Mouse
Isotype: IgG2b, kappa
Reactivity: Human



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Size Supplier No. VWR Catalog Number Unit Price Quantity
50 μL BNUM0488-50 75977-392 Each (50µl) Retrieving Restricted

Temperature sensitive This Item is temperature-controlled and may have specific temperature and storage requirements for shipping/delivery.

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Antigen Symbol TOP1MT
Antigen Name Topoisomerase I MT
Reactivity Human
Conjugation Unconjugated
Clonality Monoclonal
Antibody Type Primary
Clone TOP1MT/488
Host Mouse
Isotype IgG2b, kappa
ImmunoChemistry Yes
Gene ID Unigene ID: 528574
Concentration 1 mg/mL
Storage Buffer PBS, no BSA, no azide
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