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Anti-HIF1A Mouse Monoclonal Antibody (CF770) [clone: Clone HIF1A-84]

Supplier: Biotium
BNC700084-100 BNC700084-500
HIF1 (hypoxia-inducible factor 1), a heterodimeric transcription factor complex central to cellular response to hypoxia, consists of two subunits (HIF-1 alpha and HIF-1 beta) which are basic helix-loop-helix proteins of the PAS (Per, ARNT, Sim) family. Expression of HIF-1 alpha protein is regulated by cellular oxygen level alterations as well as in oxygen-independent manner via different cytokines (through the PI3K-AKT-mTOR pathway), growth factors, oncogenic activation, or loss of tumor suppressor function etc. In normoxic cells, HIF-1 alpha is proline hydroxylated leading to a conformational change that promotes its binding to the VLH (von Hippel Lindau) protein E3 ligase complex; ubiquitination and followed by rapid proteasomal degradation. Hypoxia as well as chemical hydroxylase inhibitors (desferrioxamine, cobalt etc.) inhibit HIF-1 alpha degradation and lead to its accumulation in the cells, whereas, contrastingly, HIF-1 beta/ARNT (AhR nuclear translocator) remains stable under both conditions. Besides their critical role in hypoxic response, HIF1s regulates the transcription of genes responsible for angiogenesis, erythropoiesis/iron-metabolism, glucose metabolism, cell proliferation/survival, adipogenesis, carotid body formation, B lymphocyte development and immune reactions.

CF® dyes are Biotium's next-generation fluorescent dyes. CF®770 is a near-infrared fluorescent dye (Ex/Em 770/797 nm) with exceptional brightness for in vivo imaging or near-IR western blotting.

Type: Primary
Antigen: HIF1A
Clonality: Monoclonal
Clone: Clone HIF1A-84
Conjugation: CF770
Epitope:
Host: Mouse
Isotype: IgG2b, kappa
Reactivity: Human




 

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Size Supplier No. VWR Catalog Number Unit Price Quantity
100 μL BNC700084-100 75952-900 Each (100µl) Retrieving Restricted

Temperature sensitive This Item is temperature-controlled and may have specific temperature and storage requirements for shipping/delivery.

500 μL BNC700084-500 75952-902 Each (500µl) Retrieving Restricted

Temperature sensitive This Item is temperature-controlled and may have specific temperature and storage requirements for shipping/delivery.

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SPECIFICATIONS

Antigen Symbol HIF1A
Antigen Name HIF1-alpha
Reactivity Human
Conjugation CF™ 770
Clonality Monoclonal
Antibody Type Primary
Clone HIF1A-84
Host Mouse
Isotype IgG2b, kappa
ImmunoFluorescence Yes
Gene ID Unigene ID: 597216
Concentration 0.1 mg/mL
Storage Buffer PBS/0.1% BSA/0.05% azide
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