FrPbAII

Synonyms: L-2-Amino-5-ureidopentanamide

BML-EA150-0005
89157-520EA 404.44 USD
89157-520
FrPbAII
FrPbAII

Selective inhibitor of GABA and glycine uptake


FrPbAII is a component of the Parawixia bistriata spider venom. It has been shown to be a selective inhibitor of GABA and glycine uptake (IC50=65µM and 62µM respectively) with little or no effect on monoamine or glutamate transporters. It produces neuroprotective effects in a rat retinal ischemia/reperfusion model displaying remarkable reduction in cell death. It also abolishes convulsive tonic-clonic seizures induced by bicuculline (Prod. No. BML-EA149) in rats. Active in vivo. Crosses the blood-retina barrier.

Formula: C₆H₁₄N₄O₂.HCl
CAS Number: 214975-80-1

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